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Apolipoprotein E ε4 allele is associated with Parkinson disease risk in a Mexican Mestizo population

Identifieur interne : 001114 ( Main/Exploration ); précédent : 001113; suivant : 001115

Apolipoprotein E ε4 allele is associated with Parkinson disease risk in a Mexican Mestizo population

Auteurs : Marisol L Pez [Mexique] ; Jorge Guerrero [Mexique] ; Petra Yescas [Mexique] ; Marie-Catherine Boll [Mexique] ; Itziar Familiar [Mexique] ; Adriana Ochoa [Mexique] ; Astrid Rasmussen [Mexique] ; María Elisa Alonso [Mexique]

Source :

RBID : ISTEX:1F26F976DA25D22D7F6FA08029AC30197ED4BF7B

English descriptors

Abstract

We investigated the association between apolipoprotein E (APOE) alleles and genotypes and Parkinson disease (PD) in 229 unrelated Mexican Mestizo PD patients and 229 controls. Results showed that both APOE‐ε4 allele and APOE ε4/ε3 genotype are associated with PD (OR = 1.736, P = 0.011; OR = 1.688, P = 0.019, respectively). Mean age at onset of PD was not associated to any APOE allele or genotype, but was significantly earlier in familial PD when compared to sporadic cases (P = 0.025). © 2006 Movement Disorder Society

Url:
DOI: 10.1002/mds.21340


Affiliations:


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Le document en format XML

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<div type="abstract" xml:lang="en">We investigated the association between apolipoprotein E (APOE) alleles and genotypes and Parkinson disease (PD) in 229 unrelated Mexican Mestizo PD patients and 229 controls. Results showed that both APOE‐ε4 allele and APOE ε4/ε3 genotype are associated with PD (OR = 1.736, P = 0.011; OR = 1.688, P = 0.019, respectively). Mean age at onset of PD was not associated to any APOE allele or genotype, but was significantly earlier in familial PD when compared to sporadic cases (P = 0.025). © 2006 Movement Disorder Society</div>
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